Computational design of protein self-assembly.
By Christoffer H Norn, Ingemar André. 2016
53 citations recorded by the source corpus.
Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries. Here, we discuss some of the underlying biophysical principles of self-assembly that influence the design problem and highlight methodological advances that have made self-assembly design a fruitful area of protein design.
Subfields: Biomaterials, Molecular Biology
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Citations in the corpus
- De novo protein design, a retrospective (2020, background): “De novo design of complex assemblies is rapidly expanding in manifold directions, and several recent reviews of the area are available (De Santis and Ryadnov, 2015; Norn and Andre, 2016; Kobayashi and Arai, 2017; Yeates, 2017; Beesley and Woolfson, 2019).”