Animal models of acute lung injury
By G. Matute-Bello, C. Frevert, T. Martin. American Journal of Physiology - Lung cellular and Molecular Physiology, 2008
1,675 citations recorded by the source corpus.
Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.
Subfields: Biomedical Engineering, Immunology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/a5249e008b87f27543e282aa6b0e9e0ad2ffd5a5
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In Biomedical Engineering
In Immunology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. (2011, background): “However, no animal model completely reproduces all of the histological features of DAD in humans (7, 13).”
- Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients (2020, neutral): “In patientswith ARDS, the alveolar spaces are occupied by the infiltrating neutrophils and monocytes (Matute-Bello et al., 2008), suggesting the pathogenic role of those cells.”