Sustained proliferation in cancer: mechanisms and novel therapeutic targets
By M. Feitelson, A. Arzumanyan, Rob J. Kulathinal, S. Blain, R. Holcombe, J. Mahajna, M. Marino, M. Martínez‐Chantar, R. Nawroth, I. Sánchez-García and 24 more. Seminars in Cancer Biology, 2015
685 citations recorded by the source corpus.
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). This data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.
Subfields: Epidemiology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/dc320918247b25dcaaaffa0a6a3011ea37bfb6aa
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Citations in the corpus
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “HIF-1 stimulates the production of growth factors, such as transforming growth factor- (TGF- ), insulin-like growth factor 2, and growth factor receptors, such as the epidermal growth factor receptor (EGFR), resulting in continuous proliferative signaling (146).”
- Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Constitutive activation of many signal transduction pathways also stimulates cell growth [46].”
- Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line (2025, unknown): “Uncontrolled proliferation, a hallmark of cancer, is driven by genetic mutations, disrupted cell cycle checkpoints, and tumor microenvironments like hypoxia, leading to tumor growth, metastasis, and therapy resistance [43].”