Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography

By J. P. Campbell, Miao Zhang, T. Hwang, Steven T. Bailey, David J. Wilson, Yali Jia, David Huang. Scientific Reports, 2017

788 citations recorded by the source corpus.

Optical coherence tomography angiography (OCTA) is a noninvasive method of 3D imaging of the retinal and choroidal circulations. However, vascular depth discrimination is limited by superficial vessels projecting flow signal artifact onto deeper layers. The projection-resolved (PR) OCTA algorithm improves depth resolution by removing projection artifact while retaining in-situ flow signal from real blood vessels in deeper layers. This novel technology allowed us to study the normal retinal vasculature in vivo with better depth resolution than previously possible. Our investigation in normal human volunteers revealed the presence of 2 to 4 distinct vascular plexuses in the retina, depending on location relative to the optic disc and fovea. The vascular pattern in these retinal plexuses and interconnecting layers are consistent with previous histologic studies. Based on these data, we propose an improved system of nomenclature and segmentation boundaries for detailed 3-dimensional retinal vascular anatomy by OCTA. This could serve as a basis for future investigation of both normal retinal anatomy, as well as vascular malformations, nonperfusion, and neovascularization.

Subfields: Biomedical Engineering, Ophthalmology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/dc26a7e2b476a210a0e300c0ca952043e4f79075

How researchers see this paper

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In Biomedical Engineering

1. R. Spaide
2. Nadia K. Waheed
3. SriniVas R. Sadda
4. G. Staurenghi
5. James G. Fujimoto
6. Michael A. D. Taylor
7. Warwick P. Bowen

In Ophthalmology

1. Nadia K. Waheed
2. SriniVas R. Sadda
3. G. Staurenghi
4. James G. Fujimoto
5. R. Spaide

In Radiology, Nuclear Medicine and Imaging

1. Nadia K. Waheed
2. James G. Fujimoto
3. SriniVas R. Sadda
4. G. Staurenghi
5. R. Spaide

Citations in the corpus

• Optical coherence tomography angiography (2017, background): “…have suggested that the macular retinal circulation can be visualized in its principle component parts, the radial peripapillary capillary plexus, the superficial vascular plexus, the intermediate capillary plexus, and the deep capillary plexus (Campbell et al., 2017; Zhang et Prog Retin Eye Res.”