Prostaglandin E Receptors*
By Y. Sugimoto, S. Narumiya. Journal of Biological Chemistry, 2007
1,012 citations recorded by the source corpus.
Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE2 designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression. This molecular and biochemical heterogeneity of PGE receptors leads to PGE2 being the most versatile prostanoid. Studies on knock-out mice deficient in each EP subtype have defined PGE2 actions mediated by each subtype and identified the role each EP subtype plays in various physiological and pathophysiological responses. Here we review recent advances in PGE receptor research.
Subfields: Genetics, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/dc1f22361b6bb78f2c9d6d8dee6274a1b303ccef
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Citations in the corpus
- Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle (2009, positive): “In addition, PGE has an important role in the mammalian immune response, acting through prostaglandin E receptors 2 and 4 (PTGER2 and PTGER4) to control inflammation [66].”
- Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? (2008, background): “The prostaglandin receptors that mediate many of the effects of prostanoids on mucosal defense have been characterized through the use of pharmacological probes and knock-out mice (167) (Table 1).”