Initiation of protein synthesis in eukaryotic cells.

By V. M. Pain. 1996

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Current development of mTOR inhibitors as anticancer agents (2006, background): “4EBP1 is a small protein that represses the initiation of protein translation through its association with eIF4E, the mRNA cap-binding subunit of the eIF4F comple”
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. (2001, background): “Gene expression protein biosynthesis, regulation by phosphorylation of analysis indicated that eIF2 phosphorylation is reeukaryotic translation initiation factor 2 on the subunit quired for the transcriptional adaptive response to ER (eIF2 ) attenuates protein synthesis in all eukaryotic cells (Pain”
Phosphorylation of initiation factor‐2α is required for activation of internal translation initiation during cell differentiation (2002, unknown): “Control of eIF4E activity is mediated by influencing its phosphorylation status and/or its interaction with the eIF4E binding proteins, as well as by affecting the integrity of eIF4G which serves as an adapter protein that bridges eIF4E, the RNA helicase eIF4A, poly(A) binding protein and eIF3 (revi”