Innate immunity to influenza virus infection

By A. Iwasaki, Padmini S. Pillai. Nature reviews. Immunology, 2014

1,022 citations recorded by the source corpus.

Influenza viruses are a major pathogen of both humans and animals. Recent studies using gene-knockout mice have led to an in-depth understanding of the innate sensors that detect influenza virus infection in a variety of cell types. Signalling downstream of these sensors induces distinct sets of effector mechanisms that block virus replication and promote viral clearance by inducing innate and adaptive immune responses. In this Review, we discuss the various ways in which the innate immune system uses pattern recognition receptors to detect and respond to influenza virus infection. We consider whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and propose rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/dc0443d52e23fcb63dfd9a72e6191141c0804ef1

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Citations in the corpus

SARS-CoV-2 and viral sepsis: observations and hypotheses (2020, background): “18 However, little is known about the situation in COVID-19 at this moment.”
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways (2016, neutral): “Innate sensors of IAV have been well characterized, however all known IAV-receptors recognize viral RNA in infected cells (2).”
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, neutral): “However, mounting evidence suggests that each type of IFN might have a non-redundant role in host defense or immunopathology, particularly at epithelial barriers (Broggi et al., 2020; Iwasaki et al., 2017; Iwasaki and Pillai, 2014; Jewell et al., 2010).”