Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder.

By Vladimir N Uversky. Current Opinion in Structural Biology, 2017

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Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics (2019, background): “The structural integrity and biogenesis of PMLOs are both exclusively determined by protein–protein, protein–RNA, and/or protein–DNA interactions [207, 208], and the process of PMLO formation is highly controlled, completely reversible, and strongly condition-dependent [181, 182].”
Transcription factors activate genes through the phase separation capacity of their activation domains (2018, background): “Many of these features have been described for IDRs that are capable of forming phase-separated condensates (Babu, 2016; Darling et al., 2018; Das et al., 2015; Dunker et al., 2015; Habchi et al., 2014; van der Lee et al., 2014; Oldfield and Dunker, 2014; Uversky, 2017; Wright and Dyson, 2015).”
Protein Phase Separation: A New Phase in Cell Biology (2018, background): “, stress granules (SGs), processing bodies, the centriole] [2,3].”