Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

By M. Nelson, A. Kuryatov, Catherine H. Choi, Yan Zhou, J. Lindstrom. 2003

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Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function (2009, background): “For instance, 4 2-containing nAChRs can be constructed to the final stoichiometry of ( 4)2( 2)3, ( 4)3( 2)2, and ( 4)2( 2)2( 5) (339, 524).”
Neuronal nicotinic receptors: from structure to pathology. (2004, background): “…with low ACh affinity and slow desensitisation but, when the cells are transiently transfected with the b2 subunit, exposed overnight to nicotine (Nic) or kept at a low temperature (29 8C), there is an increase in the number of receptors that are more sensitive to activation (Nelson et al., 2003).”
Ca2+ Permeability of the (α4)3(β2)2 Stoichiometry Greatly Exceeds That of (α4)2(β2)3 Human Acetylcholine Receptors (2006, background): “…2)2 stoichiometry has been shown to differ from the ( 4)2( 2)3 stoichiometry in that it is less sensitive to nicotineinduced up-regulation caused by increased assembly as a result of pharmacological chaperone effects of nicotine (Nelson et al., 2003; Kuryatov et al., 2005; Moroni et al., 2006).”