PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
By S. Marx, S. Reiken, Yuji Hisamatsu, T. Jayaraman, D. Burkhoff, N. Rosemblit, A. Marks. Cell, 2000
2,141 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/db9ef0ea3c85476db9c1110e07eb1ed9c98f75ef
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). (2001, background): “6, the regulatory subunit that stabilizes the RyR2 channel (15).”
- Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor (2004, background): “added CaMKII, and (4) endogenous CaMKII targeted to RyR2 activated by Ca(2) and calmodulin (CaM) (Figure 4A).”
- Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “Hyperphosphorylation of RyR2 has been observed in the failing human heart (Marx et al. 2000; Respress et al. 2014); however, the precise role of RyR2 phosphorylation in the pathogenesis of HF and arrhythmias is the subject of intense debate (Dobrev and Wehrens 2014; Fig.”
- Ryanodine receptors: structure, expression, molecular details, and function in calcium release. (2010, background): “Such leaky channels could underlie increased risk for arrhythmias in heart failure and contribute to decreased muscle force production by reducing SR Ca2þ store content (Marx et al. 2000; Reiken et al. 2003).”
- Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. (2007, background): “Another important area in rapid development is the study of ion-channel subunit assembly along with related and regulating proteins in specialized membrane microdomains (160, 182, 188).”