Biology of mammalian L1 retrotransposons.

By E. Ostertag, Haig H. Kazazian. Annual Review of Genetics, 2001

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Rapid DNA methylation changes after exposure to traffic particles. (2009, background): “Hypomethylation of repetitive DNA sequences is expected to lead to the transcriptional activation of those repetitive sequences that still contain active promoters, potentially resulting in disruption of transcription factor balance, sense or antisense transcriptional interference, and production of”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “L1-derived DNA fragments mapped preferentially to the 3 0 end of the consensus L1 sequence , which may reflect the abundance of defective, 5 0 deleted L1 elements in the mouse genome (Figure 5G) (Ostertag and Kazazian, 2001).”
An initial map of insertion and deletion (INDEL) variation in the human genome. (2006, background): “Transposable genetic elements, by integrating into genomes, also produce DNA insertions that may cause human diseases (Ostertag and Kazazian 2001).”
DNA hypomethylation and human diseases. (2007, background): “Alu-made polymorphisms can be associated with increased disease risk [77] and Alu-mediated chromosomal rearrangements, insertions/deletions and complex recombinations have accounted for over 20 different cases of human genetic disease [58].”