SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly

By T. Biederer, Y. Sara, M. Mozhayeva, Deniz Atasoy, Xinran Liu, E. Kavalali, T. Sūdhof. Science, 2002

823 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/db35ab96ccc8b6e2fc144ac7b492edd4bc500ea9

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In Cellular and Molecular Neuroscience

1. R. Gerardy-Schahn
2. H. Hildebrandt
3. Yunhee Kang
4. Ann Marie Craig
5. R. Schnaar
6. Vasilis Ntziachristos

Citations in the corpus

• Cell adhesion molecules: signalling functions at the synapse (2007, background): “A member of the Ig superfamily, synaptic cell adhesion molecule (SynCAM) was identified in a search for proteins with an extracellular Ig domain and an intracellular PDZ binding domai”
• Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “Like NCAM, SynCAM 1 is a member of the Ig superfamily with a short cytosolic domain, a single membrane span and extracellular Ig-like domains containing potential N-glycosylation sites (39) (FIGURE 15B).”
• A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms (2011, background): “SynCAMs play an important role in establishing and stabilizing synapses through Ca-independent interactions, in contrast to Ca-dependent neurexin-neuroligin interactions [34].”
• Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, neutral): “, 2000), does not rule out this model; in this assay, a small number of synapses are also formed on control cells (Biederer et al., 2002), suggesting that even in the absence of a neural celladhesion molecule, some synapses are transiently formed.”
• PDZ domain proteins of synapses (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=20969">syndecan and SynCA”
• Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Overexpression of SynCAM in nonneuronal cells induces formation of synapses with axons of cocultured neurons (Biederer et al., 2002).”
• Neurexin-neuroligin signaling in synapse development. (2007, background): “Complementary studies on SynCAMs [53], ephrins and Eph receptors [54], synaptic adhesion-like molecules [55,56] and netrin-G ligands [57] indicate that additional cell adhesion molecules are specific for glutamatergic as opposed to GABAergic synapses, and that these molecules can also link to postsy”
• Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq (2018, background): “, 2018) and Cadm1 (Biederer et al., 2002; Robbins et al., 2010), membrane vesicle traffickers Syt1 and Syt4, Actb which constitutes the predominant synapse cytoskeletal protein, and others with a strong connection to synapse biology such as Ywhaz (Foote et al.”