Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
By S. Swan. Environmental Research, 2008
794 citations recorded by the source corpus.
After briefly discussing human exposure to phthalates --diesters of 1,2-benzenedicarboxylic acid (phthalic acid) -- this article first presents recent findings from the Study for Future Families, a multi-center pregnancy study in which the human analogue of the phthalate syndrome was first identified. This is one of an increasing number of studies that have investigated human endpoints in relation to environmental exposure to these ubiquitous compounds. This literature, which includes a range of human health endpoints following prenatal, neonatal, childhood and adult exposures, is then summarized. At least one significant association has been reported for urinary metabolites of di-n-butyl phthalate (DBP), butylbenzyl phthalate (BzBP), diethyl phthlate (DEP) and di-isononyl phthalate (DINP) and for three of the urinary metabolites of di(2-ethylhexyl) phthalate (DEHP). Many of the findings reported in humans –most of which have been in males-- are consistent with the anti-androgenic action that has been demonstrated for several phthalates. Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes.
Subfields: Health, Toxicology and Mutagenesis
View Paper: https://www.semanticscholar.org/paper/db09d908f16eb67c4b481a3abefe56d20eddbb37
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Health, Toxicology and Mutagenesis
Citations in the corpus
- Assessing exposure to phthalates - the human biomonitoring approach. (2011, positive): “Some recent epidemiologic studies suggest that internal exposure to a number of phthalates at environmental levels may be associated with alterations in semen parameters [45–47], DNA damage in sperm [48, 49], reduced reproductive hormone levels in adult men [50], decreased anogenital distance in mal”
- Plastics, the environment and human health: current consensus and future trends (2009, background): “An initial attempt at examining more than one phthalate as a contributor to abnormal genital development in babies has shown the importance of this approach (Swan 2008).”
- A Review of Biomonitoring of Phthalate Exposures (2019, background): “In addition, phthalate exposure might be linked to insulin resistance and obesity in human populations [39,40].”
- Phthalates and other additives in plastics: human exposure and associated health outcomes (2009, methodology): “6 months at exam) males shorter anogenital distance MEHP, MEOHP, MEHHP, MEP, MBP Swan (2008)”