Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

By Qing Yu, Renate König, S. Pillai, Kristopher Chiles, Mary F. Kearney, S. Palmer, D. Richman, J. Coffin, N. Landau. Nature Structural &Molecular Biology, 2004

636 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/dad8029d6c6952d090df2595748d1196411a7370

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In Infectious Diseases

1. Y. Ho

Citations in the corpus

• Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure (2013, background): “Although the gag gene was analyzed here, other regions of the genome show even greater hypermutation (Yu et al., 2004).”
• Retroviral restriction by APOBEC proteins (2004, background): “In support of such a mechanism, purified APOBEC3G has been shown to preferentially deaminate cytosine residues in single-stranded DNA but not in DNA–RNA hybrids or double-stranded DNA substrate”