PKCϵ controls the traffic of β1 integrins in motile cells

By J. Ivaska, Richard D. H. Whelan, R. Watson, P. Parker. 2002

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PKD1/PKCμ promotes αvβ3 integrin recycling and delivery to nascent focal adhesions (2004, background): “Internalisation of b1 integrins is regulated by PKC-a (Ng et al, 1999), and PKC-e (Ivaska et al, 2002) has a role in controlling an endosomal transport step that permits recy- cling of integrin to the plasma membrane.”
Structural Basis of Protein Kinase C Isoform Function (2008, background): “However, chronic PKC inhibition also leads to a defect in PKC -dependent phosphorylation of the intermediate filament protein vimentin (which is required for vesicular transport and protein trafficking) and the accumulation of PKC in large 1integrin-containing cytoplasmic vesicles, leading to abnorm”
PKCε‐mediated phosphorylation of vimentin controls integrin recycling and motility (2005, methodology): “In initial studies on proximal components of PKCe action involved in recycling/migration, it was shown that the com- bined presence of cytosol, ATP and GTP were required for significant release of PKCe from the vesicle compartment in vitro (Ivaska et al, 2002).”