Ca2+/Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca2+ Leak in Heart Failure

By Xun Ai, J. Curran, T. Shannon, Donald M. Bers, S. Pogwizd. Circulation Research, 2005

742 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Electrochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/da47c3ac4aa6bbf00d9bd329d11f0019a2975905

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In Cardiology and Cardiovascular Medicine

1. Stanley Nattel

Citations in the corpus

• Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. (2007, background): “Delayed afterdepolarizations occur in congestive heart failure despite reduced cell Ca(2) stores because of a number of features of cardiac failure-induced ion transport remodeling (4, 245, 246).”
• Ryanodine receptors: structure, expression, molecular details, and function in calcium release. (2010, background): “In addition, other laboratories suggest that CamKII-dependent phosphorylation of RyR2 is involved in enhanced SR Ca2þ leak and reduced SR Ca2þ load in heart failure and may contribute to arrhythmias and contractile dysfunction (Ai et al. 2005; Chelu et al. 2009; Curran et al. 2010; Neef et al. 2010)”