Optimizing Prognostic Assessment in High‐Risk Head and Neck Squamous Cell Carcinomas: The Impact of Tumor Budding and a Novel Histomorphological Scoring System

By M. Knebel, Jan Philipp Kühn, S. Körner, F. Braun, L. Brust, S. Wemmert, S. Smola, Martin Ertz, Mathias Wagner, Bernhard Schick and 3 more. Cancer Medicine, 2025

2 citations recorded by the source corpus.

Head and neck squamous cell carcinomas (HNSCC) pose significant clinical challenges, particularly in high‐risk cases with positive lymph node status. Current prognostic biomarkers are often costly and methodologically demanding. In this regard, histomorphological biomarkers such as tumor buds (TB) and poorly differentiated clusters (PDC) represent promising, cost‐effective prognostic indicators that are relatively straightforward to implement.

Subfields: Oncology, Otorhinolaryngology, Pathology and Forensic Medicine

View Paper: https://doi.org/10.1002/cam4.70685

Citations in the corpus

• Evaluation of Tumor Budding and Poorly Defined Clusters as Histological Biomarkers in Squamous Cell Carcinomas of the Vulva (2025, unknown): “…with HPV status as well as p53 mutational status [9]—a finding especially true for the field of head and neck cancer not only for research groups such as Stögbauer et al. but also our own studies, which showed a clear association of higher budding formation with a negative HPV status [18,19].”