The biogenesis and emerging roles of circular RNAs

By Ling-Ling Chen. Nature reviews. Molecular cell biology, 2016

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Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. (2018, background): “In addition, an increasing number of RBPs involved in circRNA biogenesis are being discovered [5], and two or more RBPs may regulate the production of circRNAs synergistically[46, 47].”
Linking Long Noncoding RNA Localization and Function. (2016, background): “Circular RNAs may regulate gene expression by titrating miRNAs, regulating transcription, or interfering with splicing (see review [81]).”
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs (2016, background): “Li Z, Huang C, Bao C, Chen L, Lin M,Wang X, Zhong G, Yu B, HuW, Dai L, et al. 2015.”
The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “Notably, one gene can generate different circRNAs, which can be affected by the competition of RNA pairing across the flanking introns [24, 25].”
Noncoding RNA:RNA Regulatory Networks in Cancer (2018, background): “CircRNAs are products of backsplicing events on precursor mRNAs with the distinctive feature of a 3′,5′-phosphodiester bond at the “backsplice junction” [147,148].”