Locus coeruleus and dopaminergic consolidation of everyday memory
By T. Takeuchi, A. Duszkiewicz, Alex Sonneborn, P. Spooner, Miwako Yamasaki, Masahiko Watanabe, Caroline C. Smith, Guillén Fernández, Karl Deisseroth, R. Greene and 1 more. Nature, 2016
681 citations recorded by the source corpus.
The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH+) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH+ neurons project more profusely than ventral tegmental area TH+ neurons to the hippocampus, optogenetic activation of locus coeruleus TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/da1773bcb0b2af27478f93240edab45f610cb668
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In Cellular and Molecular Neuroscience
- Johanni Brea
- Dane S. Corneil
- Vasiliki Liakoni
- Marco P Lehmann
- Wulfram Gerstner
- Friedemann Zenke
- Pierre Yger
- Claudia Clopath
In Cognitive Neuroscience
- Johanni Brea
- Wulfram Gerstner
- Dane S. Corneil
- Vasiliki Liakoni
- Marco P Lehmann
- Friedemann Zenke
- Andrea Soltoggio
- J. Urgen Schmidhuber
Citations in the corpus
- Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules (2018, background): “The source of dopamine could be in the Locus Coeruleus which would make a link to arousal and novelty (Takeuchi et al., 2016) or from other dopamine nuclei linked to reward (Schultz, 1998).”