The pro- and anti-inflammatory properties of the cytokine interleukin-6.

By J. Scheller, A. Chalaris, D. Schmidt-Arras, S. Rose‐John. Biochimica et Biophysica Acta, 2011

3,213 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d9fdf7243e0ae422bacb586b10a3dfefd2ee8de7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Rose‐John

In Immunology

1. E. L. Kachikwu
2. S. Rose‐John
3. W. McBride
4. D. Schaue
5. Rhiannon Morris
6. C. Mackall
7. J. Babon
8. N. Kershaw

In Oncology

1. S. Grupp
2. Neeraj Kumari
3. A. Bhatt
4. B. Dwarakanath
5. Asmita Das
6. E. L. Kachikwu
7. S. Rose‐John
8. W. McBride

Citations in the corpus

• Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “It has a characteristic structure made up of four long α-helices arranged in an up–up–down–down topology [21].”
• Current concepts in the diagnosis and management of cytokine release syndrome. (2014, background): “However, when IL-6 levels are elevated, soluble IL-6R can also initiate trans-signaling, which occurs on a much wider array of cells.(30) Current models hold that antiinflammatory properties of IL-6 are likely mediated via classic signaling, whereas proinflammatory responses occur as a result of tra”
• Obesity and inflammation: the linking mechanism and the complications (2016, background): “Subsequently, the IL-6/IL-6R complex associates with glycoprotein 130 (gp130), leading to gp130-homodimer formation and signal initiation [10].”
• IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 (2012, background): “Under physiologic conditions IL-6 is thought to act in a paracrine fashion [69].”
• The molecular details of cytokine signaling via the JAK/STAT pathway (2018, background): “Although gp130 is found ubiquitously expressed, IL-6Rα is found only on hepatocytes and some leukocytes.(236) However, soluble IL-6Rα is released from the liver and this allows”
• Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “Reportedly, the former is deemed to be neuroprotective and helps maintain neuronal homeostasis,(248) whereas the latter contributes to IL-6-induced pro-inflammatory outcomes.(249,250) IL-6 levels are upregulated during cerebral ischemia, which correlates with infarct volumes and survival rates.”
• Cytokines in Radiobiological Responses: A Review (2012, positive): “Importantly, ‘‘classic’’ IL-6 signaling has regenerative and anti-inflammatory consequences, while trans-signaling is responsible for many of IL-6s pro-inflammatory effects (20).”