Diversity of Alkane Hydroxylase Systems in the Environment
By J. V. Beilen, Zhi Li, W. Duetz, T. H. Smits, B. Witholt. 2003
378 citations recorded by the source corpus.
The first step in the aerobic degradation of alkanes by bacteria, yeasts, and fungi is catalyzed by oxygenases. These enzymes, which introduce oxygen atoms derived from molecular oxygen into the alkane substrate, play an important role in oil bioremediation and in the cometabolic degradation of compounds such as trichloroethylene and fuel oxygenates. In addition, they are useful biocatalysts and important models for a difficult chemical reaction: the regio- and stereospecific activation of C-H bonds. Several unrelated enzyme classes catalyze the oxidation of alkanes. Alkane-degrading yeast strains contain multiple alkane hydroxylases belonging to the P450 superfamily, while many bacteria contain enzymes related to the Pseudomonas putida GPo1 membrane-bound alkane hydroxylase system. Short-chain alkanes are probably oxidized by alkane hydroxylases related to the soluble and particulate methane monooxygenases. Only the membrane-bound enzymes have been studied with respect to their prevalence in environments such as soils or aquifers.
Subfields: Molecular Biology, Pollution
View Paper: https://www.semanticscholar.org/paper/d9ea941720265c1076b99008f5cfca7bae214fa5
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Citations in the corpus
- Alkane hydroxylases involved in microbial alkane degradation (2007, methodology): “However, it is clear that alkane-degraders occur in pristine environments as well (van Beilen et al. 2003b; Harayama et al. 2004).”
- Biodegradation of Polyethylene by a Soil Bacterium and AlkB Cloned Recombinant Cell (2012, background): “Hexadecane metabolic pathway flows into the TCA cycle after the hexadecane degradation by the relevant degrading enzyme through the β-oxidation [23].”