Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

By J. Justesen, K. Stenderup, E. Ebbesen, L. Mosekilde, T. Steiniche, M. Kassem. Biogerontology (Dordrecht), 2004

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Mechanisms of Disease: is osteoporosis the obesity of bone? (2006, result): “This finding was confirmed in subsequent studies that showed increased bone-marrow adiposity in postmenopausal women with osteoporosis, and a negative association between bone-marrow fat and rate of bone formation”
Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? (2016, background): “For example, increased marrow fat content has been observed in osteoporosis patients, the most common bone remodeling disorder worldwide.(7,8) Actually,”