Long-Term Follow-Up of Colonoscopic Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection

By L. Brandt, Olga C. Aroniadis, M. Mellow, Amy Kanatzar, C. Kelly, T. Park, N. Stollman, Faith Rohlke, C. Surawicz. American Journal of Gastroenterology, 2012

674 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9e863e652d2d32aeb07b8643e48d08ef468e230

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Herbert Tilg
2. J. H. Morse

In Molecular Biology

1. W. Tang
2. Stanley L Hazen
3. S. Bischoff
4. Herbert Tilg
5. T. Kitai

Citations in the corpus

• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, positive): “%) have been associated with instillation of feces via the colon [360, 363–366].”
• Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial (2019, neutral): “5) 774 (221-1768) Diet, mean (SD) Protein, g 97 (38) 109 (42) Carbohydrate, g 230 (70) 221 (102) Total Fat, g 76 (33) 86 (34) Saturated Fat, g 29 (16) 32 (15) Sugars, g 90 (36) 103 (74) Starch, g 139 (56) 115 (54) Fiber, g 19 (8) 21 (8) Calcium, mg 700 (467) 718 (447) Iron, g 11.”
• European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. (2014, background): “[171] Enema 7 0 9 months [172] Colonoscopy 13 15 5 months [173] Colonoscopy 12 0 (3 week–8 year) [174] Gastroscopy or colonoscopy 40 27 80 days [175] Colonoscopy 26 8 11 months [176] Colonoscopy 7/77 treatment failures within 90 days after treatment (early recurrence).”
• Intestinal permeability – a new target for disease prevention and therapy (2014, background): “Indeed, fecal transplantation now enters clinical medicine, after beneficial effects in patients with therapy-refractory Clostridium difficile infection have been reported [259,260].”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “difficile infection in humans, where fecal transplantation induces an 80% remission rate.(142,143)”
• Current understanding of dysbiosis in disease in human and animal models (2016, background): “The relationship between the donors and patient does not seem to affect the outcome.(92,93) FMT was originally performed through fecal enemas, subsequently also through nasoduodenal tubes (1991) and colonoscopy administration (2000).”