Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

By N. Chaput, P. Lepage, C. Coutzac, E. Soularue, K. L. Roux, C. Monot, L. Boselli, É. Routier, L. Cassard, M. Collins and 8 more. Annals of Oncology, 2017

1,133 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d9d55eff85dc39a4006f0ad00ce9c6ae209a0096

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Padmanee Sharma
2. J. Wolchok
3. James P. Allison
4. S. Wei
5. C. Robert
6. Jing Wang
7. J. Wargo
8. Antoni Ribas

In Molecular Biology

1. J. Wolchok
2. C. Robert
3. Dana Pe'er
4. F. Farzaneh
5. Yang Xie
6. J. Wargo

In Oncology

1. J. Wolchok
2. Padmanee Sharma
3. James P. Allison
4. C. Robert
5. K. Kerr
6. S. Wei
7. J. Haanen
8. J. Larkin

Citations in the corpus

• Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade (2017, positive): “Addressing these possibilities is of great interest given that expansion of ICOS CD4 T cells following ipi treatment has been observed in multiple tumor types (Chaput et al., 2017; Chen et al., 2009; Liakou et al., 2008), that expansion of ICOS CD4 T cells is associated with overall survival followi”
• Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “Moreover, fecal microbiota composition of 26 patients with metastatic melanoma, using 16S rRNA, at time 0 and before each Ipilimumab treatment, was clustered on microbiota patterns.”
• Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2017, background): “Most of the baseline colitisassociated phylotypes were related to Firmicutes (e.g. relatives of Faecalibacterium prausnitzii and Gemmiger formicilis), whereas nocolitis related phylotypes were assigned to Bacteroidetes [46].”
• Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (2018, background): “Personal ecologic factors, such as the patient’s microbiome, may also play a role in the susceptibility to specific irAEs, such as enterocolitis.(77,135,136) Further studies are needed to investigate whether a patient’s biologic profile predisposes to the occurrence of irAEs.”
• Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients (2017, positive): “16S rRNA gene sequencing of stool from melanoma patients receiving anti-CTLA4 antibody pretreatment and before each antibody infusion [36].”
• Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2018, background): “Most of the baseline colitisassociated phylotypes were related to Firmicutes (e.g. relatives of Faecalibacterium prausnitzii and Gemmiger formicilis), whereas nocolitis related phylotypes were assigned to Bacteroidetes [47].”