The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics

By Y. Sambuy, I. Angelis, G. Ranaldi, M. Scarino, A. Stammati, F. Zucco. Cell Biology and Toxicology, 2005

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Therapeutics Data Commons: Machine Learning Datasets and Tasks for Drug Discovery and Development (2021, background): “The experimental result on the rate of drug passing through the Caco-2 cells can approximate the rate at which the drug permeates through the human intestinal tissue (Sambuy et al. 2005).”
TEER measurement techniques for in vitro barrier model systems (2015, background): “The culture period is considered to be important for the formation of a tight junction in these cells.(124) The conventional culture period of Caco-2 cells for transport studies is considered to be 21 days.”
Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin (2016, neutral): “It is possible that the molecular profile of these patients’ cancers is not well-represented amongst our 76 expression datasets (none are lung squamous cell carcinomas; CACO-2 is a cell line derived from a colorectal adenocarcinoma, but is highly heterogeneous (Sambuy et al., 2005)).”