Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

By Hiroshi Makino, R. Malinow. 2011

224 citations recorded by the source corpus.

Synapses in the brain are continuously modified by experience, but the mechanisms are poorly understood. In vitro and theoretical studies suggest threshold-lowering interactions between nearby synapses that favor clustering of synaptic plasticity within a dendritic branch. Here, a fluorescently-tagged AMPA receptor-based optical approach was developed permitting detection of single synapse plasticity in mouse cortex. Sensory experience preferentially produced synaptic potentiation onto nearby dendritic synapses. Such clustering was significantly reduced by expression of a phospho-mutant AMPA receptor that is insensitive to threshold lowering modulation for plasticity-driven synaptic incorporation. In contrast to experience, sensory deprivation caused homeostatic synaptic enhancement globally on dendrites. Clustered synaptic potentiation produced by experience could bind behaviorally relevant information onto dendritic subcompartments; global synaptic up-scaling by deprivation could equally sensitize all dendritic regions for future synaptic input.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Electrical and Electronic Engineering

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. K. Zito
2. Won Chan Oh
3. Laxmi Kumar Parajuli

Citations in the corpus

• Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons (2014, background): “, 2008) and in vivo (Fu et al., 2012; Makino and Malinow, 2011).”