Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

By G. Ankley, R. S. Bennett, R. Erickson, Dale J. Hoff, M. W. Hornung, Rodney D. Johnson, D. Mount, J. Nichols, C. Russom, P. Schmieder and 3 more. Environmental Toxicology and Chemistry, 2010

2,447 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Pollution

View Paper: https://www.semanticscholar.org/paper/d9679a796c75ad77a7b2e049da53557e41e36690

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Richard S. Judson
2. Yuming Guo
3. D. Spurgeon
4. Ann M. Richard
5. E. Lahive

In Pollution

1. D. Spurgeon
2. E. Lahive
3. James M. Tiedje
4. Xinde Cao
5. Matthias C. Rillig
6. W. Amelung

Citations in the corpus

• Developing scientific confidence in HTS-derived prediction models: lessons learned from an endocrine case study. (2014, result): “Although not a one-to-one match, this approach is, in essence, very similar to a well-informed adverse outcome pathway (AOP) that includes support for a causal link between the key event and adverse outcome (Ankley et al., 2010).”
• Emerging contaminants: A One Health perspective (2024, positive): “454 Because the experimental design of metabolomic approaches is highly versatile, it can be applied to study multiple scenarios with various environmental conditions and different organisms, as well as complex contaminant mixtures and wastewater ef fl uents.”
• Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications (2020, background): “Dallinger, R., and Hockner, M. (2013). Evolutionary concepts in ecotoxicology:”
• WikiPathways: connecting communities (2020, background): “Since the introduction of Adverse Outcome Pathways (AOPs) to support regulatory decision making for risk assessment of chemicals (24), the primary focus of AOP research groups has been capturing mechanistic data in written format.”
• Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes (2015, positive): “These observations indicate multiple molecular initiating events and intermediate key events leading to MRDT adverse outcomes, supporting the use of the adverse outcome pathways (AOPs) approach (Ankley et al. 2010; Sturla et al. 2014) as a model framework to assess potential MRDT chemicals.”
• A chronicle of a killer alga in the west: ecology, assessment, and management of Prymnesium parvum blooms (2015, background): “Developing adverse outcome pathways (Ankley et al., 2010) is necessary to support this pressing research need.”