CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

By M. Comb, H. Goodman. 1990

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “In contrast to most previously reported cases [for example, (9, 10, 12, 17, 18)], we found that methylation can affect TF binding positively in many cases [see also (16, 62)].”
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life (2005, methodology): “…LG-ABN mothers were infused with methionine (100 ␮g/ml) or saline vehicle once a day for 7 consecutive days, and differences in methylation were mapped using the sodium bisulfite technique (Comb and Goodman, 1990; Clark et al., 1994), with particular interest in the NGFI-A consensus sequence (Fig.”