The Chromosomal Passenger Complex (CPC): From Easy Rider to the Godfather of Mitosis
By M. Carmena, Michael S Wheelock, H. Funabiki, W. Earnshaw. Nature reviews. Molecular cell biology, 2012
936 citations recorded by the source corpus.
Successful cell division requires the precise and timely coordination of chromosomal, cytoskeletal and membrane trafficking events. These processes are regulated by the competing actions of protein kinases and phosphatases. Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC). This complex targets to different locations at differing times during mitosis, where it regulates key mitotic events: correction of chromosome–microtubule attachment errors; activation of the spindle assembly checkpoint; and construction and regulation of the contractile apparatus that drives cytokinesis. Our growing understanding of the CPC has seen it develop from a mere passenger riding on the chromosomes to one of the main controllers of mitosis.
Subfields: Food Science, Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/d9327fdfd20e742dd53be122da5c65933128440a
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Citations in the corpus
- PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP (2015, background): “In fact, this interaction is shown to enable AURKB to phosphorylate a C-terminal TSS (threonine-serine-serine) motif in INCENP and threonine 232 in the T-loop of its kinase domain, which results in full activation of AURKB [10-12].”