Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
By Charlotte L. Scott, Fang Zheng, P. De Baetselier, L. Martens, Yvan Saeys, Sofie De Prijck, S. Lippens, C. Abels, S. Schoonooghe, G. Raes and 4 more. Nature Communications, 2016
767 citations recorded by the source corpus.
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them. Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/d8c5a6aa3d86ccb6292300a9422b55c7333e65da
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In Immunology
Citations in the corpus
- Hepatic inflammatory responses in liver fibrosis (2023, unknown): “Hepatic macrophages, that mainly comprise tissue-resident Kupffer cells and monocyte-derived macrophages (MoMFs), are characterized by a high phenotypic and functional diversity and plasticity 11,71,72 .”
- Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, background): “Of these, tissue of residence is the major contributor, with the ability to almost completely reprogram ontogenically defined identity (29, 30, 51, 52).”
- Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches (2022, methodology): “Clec4f-Dtrmice (Scott et al., 2016) were crossed toCD45.”