Molecular coordination of αβ T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

By George F. Gao, Z. Rao, J. Bell. 2002

122 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/d8c47efa42c77d8700a5f8c60f8e30ae838efccb

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In Immunology

1. D. Mathis
2. C. Benoist
3. T. Yamagata
4. Alexander Y. Rudensky
5. Steven Z. Josefowicz
6. T. Malek
7. I. Castro

Citations in the corpus

• Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells (2004, background): “The shutoff of CD8β gene expression, in a single molecular switch, eliminates the CD8αβ coreceptor required for effective signaling 'downstream' of classical TCR–MHC class I molecule engagements and brings out the CD8αα coreceptor, a TCR-independent ligand for the nonclassical MHC class I molecule T”