Protein kinase Cδ controls self-antigen-induced B-cell tolerance

By Ingrid Mecklenbräuker, Kaoru Saijo, Nai-Ying Zheng, M. Leitges, A. Tarakhovsky. Nature, 2002

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NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, background): “…data in both studies are not entirely consistent: whereas one suggests that pkcδ−/− mice do not show a generalized enhancement of signalling events (Mecklenbrauker et al., 2002), the other detected increased proliferation of the pkcδ−/− B cells in response to several stimuli (Miyamoto et al.,…”
The classification of glomerulonephritis in systemic lupus erythematosus revisited. (2004, background): “The development of autoimmunity in SLE has been attributed to a loss of self-tolerance due to inadequate central or peripheral deletion or silencing of autoreactive lymphocytes, leading to multiple autoantibody specificities (3).”
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement (2003, methodology): “The preparation of ex vivo –isolated cells for FACScan analysis and sorting of the lymphocyte subpopulations on FACSstar was done as describe”
The classification of glomerulonephritis in systemic lupus erythematosus revisited. (2004, background): “The development of autoimmunity in SLE has been attributed to a loss of self-tolerance due to inadequate central or peripheral deletion or silencing of autoreactive lymphocytes, leading to multiple autoantibody specificities (3).”