Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

By Durba Pal, Suman Dasgupta, Rakesh Kundu, S. Maitra, G. Das, S. Mukhopadhyay, Sukanta Ray, S. Majumdar, S. Bhattacharya. Nature Medicine, 2012

904 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5b0d38fbe48398d05137ed25165b0921d354601f

How researchers see this paper

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In Epidemiology

1. P. Calder
2. M. Rogero
3. Liangyou Rui

In Immunology

1. P. Calder
2. M. Rogero
3. Liangyou Rui

In Molecular Biology

1. M. Rogero
2. P. Calder
3. Liangyou Rui

Citations in the corpus

• Energy Metabolism in the Liver (2014, positive): “Fetuin-A, a glycoprotein secreted by the liver, acts as a NEFA carrier in the circulation, and the NEFA-fetuin-A complex binds to TLR4 and promotes inflammation and insulin resistance (204).”
• Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “The expression of TLR2 and TLR4 in the plasma membrane of monocytes has been confirmed by flow cytometry; TLR2 and TLR4-binding (by peptidoglycan and LPS, respectively) generates pro-inflammatory cytokine secretion in these cells.”
• Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, neutral): “inflammation [73,74], is associated with endothelial dysfunction [75], carotid atherosclerosis [76] and an increased risk of myocardial infarction (MI) and ischemic stroke (IS) [77] and type 2 diabetes [78].”