Alcoholic liver disease: mechanisms of injury and targeted treatment

By A. Louvet, P. Mathurin. Nature Reviews Gastroenterology &Hepatology, 2015

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The Role of Oxidative Stress and Antioxidants in Liver Diseases (2015, background): “Although reductions in overall ALD mortality were observed in several reports on a country scale, it is more likely due to advances in disease management rather than a decrease in the prevalence of ALD, which could be supported by increases in hospital admissions for alcoholic hepatic failure and al”
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. (2019, background): “ROS are believed to be major responsible for induction of ER stress and, together with acetaldehyde, also of alcoholinduced steatosis, the latter recognizing AMPK downregulation and related SREBP1c stimulation and PPAR-α expression inhibition as critical determinants (Louvet and Mathurin, 2015).”