A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
By M. Matyskiela, Weihong Zhang, Hon-Wah Man, George Muller, G. Khambatta, Frans Baculi, Matthew Hickman, L. LeBrun, B. Pagarigan, G. Carmel and 9 more. 2017
245 citations recorded by the source corpus.
Subfields: Hematology, Molecular Biology
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Citations in the corpus
- Defining the human C2H2 zinc-finger degrome targeted by thalidomide analogs through CRBN (2018, methodology): “IKZF2/4 ZF2 was selectively degraded by CC-220 (Fig.”