Detection and localization of single molecular recognition events using atomic force microscopy

By P. Hinterdorfer, Y. Dufrêne. Nature Methods, 2006

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Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence (2022, background): “Therefore, a deep understanding of the principle and limitations of different AFM modalities is essential before users proceed with their first experiment [27,30].”
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy (2008, methodology): “Nonspecific adsorption remains the simplest and most common attachment method for AFM-based force spectroscopy measurements, but more sophisticated specific attachment schemes have been develope”
Critical review on biofilm methods (2017, methodology): “This method has been used to study the interaction forces of single molecules immobilized on the cantilever (Hinterdorfer & Dufrene, 2006), making it possible to map the distribution and interaction forces of e.g. lectin – polysaccharide interactions on the surface of living cells (Francius et al.,…”
Interfacial re-arrangement in initial microbial adhesion to surfaces (2010, positive): “Single molecule ligand–receptor interaction forces have been measured by attaching ligands to the AFM tip [21,61].”
Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology. (2008, methodology): “During recent years, SMFS with biologically modified tip”