Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

By E. Riquelme, Yu Zhang, Liangliang Zhang, M. Montiel, Michelle Zoltan, W. Dong, P. Quesada, I. Sahin, Vidhi Chandra, Anthony Lucas and 21 more. Cell, 2019

1,316 citations recorded by the source corpus.

SUMMARY Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5-years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S rRNA gene sequencing, we analyzed the tumor microbiome composition in PDAC patients with short and long-term survival (STS, LTS). We found higher alpha-diversity in the tumor microbiome of LTS patients and identified an intra-tumoral microbiome signature (Pseudoxanthomonas/Streptomyces/Saccharopolyspora/Bacillus clausii) highly predictive of long term survivorship in both discovery and validation cohorts. Through human-into-mice Fecal Microbiota Transplantation (FMT) experiments from STS, LTS or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. Our study demonstrates that PDAC microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d7478d7679f7b41b2a0652a76473a60cb1cc572a

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In Cancer Research

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Citations in the corpus

• The microbiome and human cancer (2021, background): “(18, 19, 25, 46, 112), gut communication (15, 20, 23), hematogenous spread (172, 173), and intrametastatic”
• Interaction between microbiota and immunity in health and disease (2020, background): “Interestingly, the intra-tumor microbiome in long-term survivors of PDAC patients exhibits higher microbial diversity, which may induce potent immune infiltration and antitumor immunity.(199) These studies indicate the potential of tumor tissue-resident microbiota as a therapeutic target, which warr”
• Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment (2023, neutral): “24,25 However, whether intratumoral bacteria are passive inhabitants or active participants that impact tumor development is an intriguing emerging question.”