Clinical diagnosis and staging of cholangiocarcinoma
By B. Blechacz, M. Komuta, T. Roskams, G. Gores. Nature Reviews Gastroenterology &Hepatology, 2011
699 citations recorded by the source corpus.
Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Currently, cholangiocarcinoma is classified into the following types according to its anatomic location along the biliary tree: intrahepatic, perihilar or distal extrahepatic cholangiocarcinoma. These cholangiocarcinoma types differ in their biological behavior and management. The appropriate stratification of patients with regard to the anatomic location and stage of cholangiocarcinoma is a key determinate in their management. Staging systems can guide this stratification and provide prognostic information. In addition, staging systems are essential in order to compare and contrast the outcomes of different therapeutic approaches. A number of staging systems exist for cholangiocarcinoma—several early ones have been updated, and new ones are being developed. We discuss the emerging diagnostic criteria as well as the different staging systems for cholangiocarcinoma, and provide a critical appraisal regarding these advances in biliary tract malignancies.
Subfields: Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/d70ec5404ac426fe0da77dac316141e48da30c02
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Citations in the corpus
- Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma (2013, methodology): “Of these, MRI plus magnetic resonance cholangiopancreatography is the preferred imaging modality because it can assess resectability and tumor extent with an accuracy of up to 95%.(2) Endoscopic ultrasound aids in evaluation for the presence of regional lymphadenopathy and omental metastasis via fin”
- The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “CCA is a histologically, genetically, and anatomically heterogeneous malignancy that is typically subdivided into perihilar, extrahepatic, and intrahepatic cholangiocarcinoma (iCCA), according to anatomical location (165, 166).”
- Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. (2014, background): “We suggest bile duct cancers could be sub-classified as iCCA, pCCA, or dCCA with the term Klatskin being omitted altogether [4,31,32].”