Prevalence of the Congenital Long QT Syndrome
By P. Schwartz, M. Stramba-Badiale, L. Crotti, M. Pedrazzini, A. Besana, G. Bosi, F. Gabbarini, K. Goulene, R. Insolia, S. Mannarino and 6 more. Circulation, 2009
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Background— The prevalence of genetic arrhythmogenic diseases is unknown. For the long-QT syndrome (LQTS), figures ranging from 1:20 000 to 1:5000 were published, but none was based on actual data. Our objective was to define the prevalence of LQTS. Methods and Results— In 18 maternity hospitals, an ECG was performed in 44 596 infants 15 to 25 days old (43 080 whites). In infants with a corrected QT interval (QTc) >450 ms, the ECG was repeated within 1 to 2 weeks. Genetic analysis, by screening 7 LQTS genes, was performed in 28 of 31 (90%) and in 14 of 28 infants (50%) with, respectively, a QTc >470 ms or between 461 and 470 ms. A QTc of 451 to 460, 461 to 470, and >470 ms was observed in 177 (0.41%), 28 (0.06%), and 31 infants (0.07%). Among genotyped infants, disease-causing mutations were found in 12 of 28 (43%) with a QTc >470 ms and in 4 of 14 (29%) with a QTc of 461 to 470 ms. One genotype-negative infant (QTc 482 ms) was diagnosed as affected by LQTS on clinical grounds. Among family members of genotype-positive infants, 51% were found to carry disease-causing mutations. In total, 17 of 43 080 white infants were affected by LQTS, demonstrating a prevalence of at least 1:2534 apparently healthy live births (95% confidence interval, 1:1583 to 1:4350). Conclusions— This study provides the first data-based estimate of the prevalence of LQTS among whites. On the basis of the nongenotyped infants with QTc between 451 and 470 ms, we advance the hypothesis that this prevalence might be close to 1:2000. ECG-guided molecular screening can identify most infants affected by LQTS and unmask affected relatives, thus allowing effective preventive measures.
Subfields: Cardiology and Cardiovascular Medicine
View Paper: https://www.semanticscholar.org/paper/d6fee93485a3d68a9b4128bb36f56ce0d1570e75
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. (2013, positive): “Among Caucasians, the prevalence of LQTS has been established by a prospective ECG study, complemented by molecular screening, performed on over 44,000 infants at age 15-25 days [5].”
- Long-QT syndrome: from genetics to management. (2012, methodology): “In total, 17 of 43,080 white infants were affected by LQTS, demonstrating a prevalence of at least 1:2,534 apparently healthy live births (95% CI, 1:1583 to 1:4350) (28).”
- HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). (2011, background): “, gender, age at onset, Tc at rest, syncope) as independent prognostic risk facors.(24) Compared with the more common potassium channel oss-of-function subtypes (LQT1 and LQT2), patients with QT3 appear to have the highest mortality per event.”
- HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). (2011, background): “, gender, age at onset, Tc at rest, syncope) as independent prognostic risk facors.(24) Compared with the more common potassium channel oss-of-function subtypes (LQT1 and LQT2), patients with QT3 appear to have the highest mortality per event.”