Ribosome biogenesis in cancer: new players and therapeutic avenues

By Joffrey Pelletier, G. Thomas, S. Volarević. Nature Reviews. Cancer, 2017

722 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d6d846afaf641fdc4d9f6fc2b73112392843b776

How researchers see this paper

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In Molecular Biology

1. Alexey I. Nesvizhskii
2. Dmitry Avtonomov
3. Andy T. Kong
4. W. Marston Linehan
5. Eric E. Schadt
6. A. Robles
7. Bing Zhang
8. Arul M. Chinnaiyan

Citations in the corpus

• Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2019, background): “Delineating a mechanism of increased ribosome biogenesis via Pol I transcription regulation (Pelletier et al., 2018), we detected a corresponding increase of protein expression for MYC-targets and mTORC1 signaling genes (p < 0.”
• Circular RNA: metabolism, functions and interactions with proteins (2020, background): “Ribosome synthesis is crucial for malignancy, and cancer is characterized by abnormal ribosomal DNA (rDNA) transcription by Pol I [167].”