Mechanism of glutamate receptor desensitization

By Yu Sun, R. Olson, M. Horning, N. Armstrong, M. Mayer, Eric Gouaux. Nature, 2002

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How researchers see this paper

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NMDA receptor subunits: function and pharmacology. (2007, background): “In AMPARs, this region forms a binding site for AMPAR-selective non-competitive antagonists of the GYKI family [39].”
Ionotropic and metabotropic glutamate receptor structure and pharmacology (2005, neutral): “The binding site for cyclothiazide was identified at the dimer interface between AMPA receptor subunits (Sun et al. 2002).”
Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “The specificity of cyclothiazide for flip splice variants arises from its interaction with Ser754, which is a larger Asn in flop variants and precludes tight cyclothiazide binding (Sun et al., 2002).”
The voltage-gated potassium channels and their relatives (2002, background): “—seem to have an important dimer relationship between their sensor domain”
Handbook of ion channels (2015, background): “CTZ also potentiates responses, possibly because it reduces the angle between LBDs in each dimer (Sun et al., 2002), in turn promoting linker separation.”