AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance

By Daniel Garcia, R. Shaw. Molecules and Cells, 2017

1,776 citations recorded by the source corpus.

AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels. The identification of numerous AMPK targets has helped explain how AMPK restores energy homeostasis. Recent advancements, however, demonstrate that regulation of AMPK is also affected by novel contexts, such as subcellular localization and phosphorylation by non-canonical upstream kinases. Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation and cancer. Moreover, the recently solved crystal structure of AMPK has shed light both into how nucleotides activate AMPK but, importantly, also into the sites bound by small molecule activators, thus providing a path for improved drugs.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/d6c1f50d30ad83051cf67460b9560a552cc14ea8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. De-chen Liu
2. Hao Li
3. Junjie Gao
4. Yao Zong
5. Peng Liao
6. Long Chen
7. Minghao Zheng
8. Changqing Zhang

Citations in the corpus

• Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “52 In addition, 99% of mitochondrial proteins are encoded by nuclear genes and imported into the mitochondrial compartments through different sorting and import machineries, which are under surveillance by cytosolic ribosomes, the ubiquitin – proteasome system, chaper-ones, and intramitochondrial…”