Current Advancements in Noninvasive Profiling of the Embryo Culture Media Secretome
By R. Zmuidinaite, F. Sharara, R. Iles. 2021
35 citations recorded by the source corpus.
There have been over 8 million babies born through in vitro fertilization (IVF) and this number continues to grow. There is a global trend to perform elective single embryo transfers, avoiding risks associated with multiple pregnancies. It is therefore important to understand where current research of noninvasive testing for embryos stands, and what are the most promising techniques currently used. Furthermore, it is important to identify the potential to translate research and development into clinically applicable methods that ultimately improve live birth and reduce time to pregnancy. The current focus in the field of human reproductive medicine is to develop a more rapid, quantitative, and noninvasive test. Some of the most promising fields of research for noninvasive assays comprise cell-free DNA analysis, microscopy techniques coupled with artificial intelligence (AI) and omics analysis of the spent blastocyst media. High-throughput proteomics and metabolomics technologies are valuable tools for noninvasive embryo analysis. The biggest advantages of such technology are that it can differentiate between the embryos that appear morphologically identical and has the potential to identify the ploidy status noninvasively prior to transfer in a fresh cycle or before vitrification for a later frozen embryo transfer.
Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
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Citations in the corpus
- Ethical Implementation of Artificial Intelligence to Select Embryos in In Vitro Fertilization (2021, background): “Examples of other developments to select embryos more likely to implant include (1) allowing embryos to self-deselect via extended culture in the laboratory [6], (2) metabolomic profiling of spent culture media [7] or (3) adding extra genetic testing such as pre-implantation genetic testing for aneu”