Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.
By M. Alarcón, B. Abrahams, J. Stone, J. Duvall, Julia V. Perederiy, J. Bomar, Jonathan Sebat, M. Wigler, C. Martin, D. Ledbetter and 3 more. American Journal of Human Genetics, 2008
844 citations recorded by the source corpus.
Subfields: Cognitive Neuroscience, Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/d621d30c8113c591913b74c4abad6a50194bea47
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- Paul M. Thompson
- Arthur W. Toga
- Mirella Dapretto
- Susan Y. Bookheimer
- Simon E. Fisher
- Jesse A. Brown
- Jeff D. Rudie
- Nicholas G. Martin
In Genetics
- Jay Shendure
- Brian J. O'Roak
- Paul M. Thompson
- Evan E. Eichler
- Deborah A. Nickerson
- Eric Boerwinkle
- Xueqiu Jian
- Xiaoming Liu
Citations in the corpus
- FOXP2 as a molecular window into speech and language. (2009, background): “Although children with autism were excluded from the SLI sample of Vernes et al. [21], a subset of SNPs were commonly associated in both studies, with the same alleles conferring risk [21, 27 ].”
- Altered Structural Brain Connectivity in Healthy Carriers of the Autism Risk Gene, CNTNAP2 (2011, positive): “Subsequent research in both autistic and language-impaired (but nonautistic) populations has discovered further support that CNTNAP2 is associated with autism (Alarco´n et al., 2008; Arking et al., 2008; Bakkaloglu et al., 2008) and language ability (Alarco´n et al., 2008; Vernes et al., 2008).”
- Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations (2011, positive): “CNTNAP2 is directly downregulated by FOXP2 35 and has been independently associated with ASD and specific language impairment 34–37 .”