Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water

By Sheng-Kwei Song, Shu-wei Sun, Michael J. Ramsbottom, Chen Chang, J. Russell, A. Cross. NeuroImage, 2002

2,658 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/d5fc9d07bd4f4d0f40a2f8c9c6cb73d5ebb7e1ce

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In Orthopedics and Sports Medicine

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Citations in the corpus

Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. (2007, background): “(Beaulieu, 2002; Song et al., 2002; Concha et al., 2006).”
Diffusion Tensor Imaging and Beyond (2011, positive): “Past studies have shown that myelin loss is correlated with an increase in perpendicular diffusivity, whereas axonal loss is related more to a decrease in the parallel diffusivity (87,88).”
The Development of Brain White Matter Microstructure (2018, background): “Axial and radial diffusivity from DTI provide increased specificity to axonal integrity, and myelin and fibre density (Song et al., 2003; Song et al., 2002; Song et al., 2005), respectively, than FA or MD.”
Radial Diffusivity Predicts Demyelination in ex-vivo Multiple Sclerosis Spinal Cords (2011, positive): “This finding corroborates previously published histopathology correlation studies in animal models (Song et al., 2002, 2003, 2005).”
Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (2010, background): “Nevertheless, the magnitude of the radial eigenvalue has been shown to be sensitive to de-and dysmyelination in mice (Song et al. 2002, 2005), suggesting some myelin specificity of RD.”
Partial volume effect as a hidden covariate in DTI analyses (2011, background): “…in radial diffusivity (RD, diffusivity perpendicular to the predominant diffusion direction) and axial diffusivity (AD, diffusivity along the predominant diffusion direction) are believed to reflect different microstructural processes in the WM (Pierpaoli et al., 2001; Song et al., 2002, 2003).”
Procedural pain and brain development in premature newborns (2012, background): “Axial diffusivity (ie, water diffusion along the longitudinal axes parallel to white matter fibers) is believed to reflect the integrity of the axon and its internal components.(33) Thus, the imaging findings point to a pain-associated impairment in axonal development.”
Assessing the effects of age on long white matter tracts using diffusion tensor tractography (2009, background): “In contrast, RD describes an average of the eigenvectors perpendicular to the principal direction ([λ 2 + λ 3 ] / 2) and is assumed to characterize changes associated with myelination or glial cell morphology (Song et al., 2002, 2003, 2005).”
White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI (2013, background): “degeneration of axons) can cause an increase in RD, while the AD remains unchanged (Song et al., 2002), see also Roosendaal et al.”
Neuroimaging of the Periaqueductal Gray: State of the Field (2011, methodology): “Several DTI based indices are used, including apparent diffusion coefficient (ADC), fractional anisotropy (FA, describing the degree of anisotropy of diffusion), axial diffusivity (a measure of diffusivity parallel to axons) and radial diffusivity (a measure of diffusivity perpendicular to fibers) (”
PANDA: a pipeline toolbox for analyzing brain diffusion images (2013, methodology): “This step involves a voxel-wise calculation of the tensor matrix and the DT metrics, including FA, MD, axial diffusivity (AD), and radial diffusivity (RD) (Pierpaoli and Basser, 1996; Song et al., 2002).”
Q-space trajectory imaging for multidimensional diffusion MRI of the human brain (2016, positive): “For demyelination, we simulated measurements on a group of parallel fibers with varying radial diffusivity (RD) while keeping the axial diffusivity (AD) fixed (AD =2.6 m2/ms, RD = 0.05 → 1.7 m2/ms), inspired by (Song et al., 2002).”
Automated Probabilistic Reconstruction of White-Matter Pathways in Health and Disease Using an Atlas of the Underlying Anatomy (2011, background): “(2010), our results show increased radial but unchanged axial diffusivity in the patients, which has been interpreted as evidence of myelin abnormalities (Song et al., 2002).”
Developmental Stages and Sex Differences of White Matter and Behavioral Development through Adolescence: A Longitudinal Diffusion Tensor Imaging (DTI) Study (2013, positive): “RD changes largelymirrored those of FA, suggesting that the majority of the developmental changes in FA are related to myelination (Song et al., 2002, 2005).”