Ion suppression in mass spectrometry.

By T. Annesley. Clinical Chemistry, 2003

1,574 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/d5f01fd567a03648a760e93e80d7771882b3bdf7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. F. Peters
2. M. Wener
3. P. Taylor
4. A. Hoofnagle
5. F. Musshoff
6. O. Drummer

In Spectroscopy

1. F. Peters
2. M. Wener
3. P. Taylor
4. A. Hoofnagle
5. F. Musshoff
6. O. Drummer

Citations in the corpus

• Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. (2005, background): “A recent paper by Annesley [20] highlighted the importance of understanding matrix effects in clinical mass spectrometry applications, and although critical to the success of an HPLC–ESI–MS/MS analytical method, few published methods adequately address this problem [21].”
• Validation of new methods. (2007, methodology): “While ESI has been reported to be much more prone to such effects, they may also occur with atmospheric pressure chemical ionisation (APCI) [18,19,32–35,37,38].”
• The Fundamental Flaws of Immunoassays and Potential Solutions Using Tandem Mass Spectrometry (2009, background): “While HPLC effectively separates the analyte of interest from many contaminants, co-eluting molecules that may vary in concentration from patient to patient can suppress the ionization of the molecule of interest (Annesley, 2003).”