Discriminatory proofreading regimes in non-equilibrium systems

By A. Murugan, D. Huse, Stanislas Leibler. 2013

96 citations recorded by the source corpus.

We use ideas from kinetic proofreading, an error-correcting mechanism in biology, to identify new kinetic regimes in non-equilibrium systems. These regimes are defined by the sensitivity of the occupancy of a state of the system to a change in its energy. In biological contexts, higher sensitivity corresponds to stronger discrimination between molecular substrates with different energetics competing in the same reaction. We study this discriminatory ability in systems with discrete states that are connected by a general network of transitions. We find multiple regimes of different discriminatory ability when the energy of a given state of the network is varied. Interestingly, the occupancy of the state can even increase with its energy, corresponding to an "anti-proofreading" regime. The number and properties of such discriminatory regimes are limited by the topology of the network. Finally, we find that discriminatory regimes can be changed without modifying any "hard-wired" structural aspects of the system but rather by simply changing external chemical potentials.

Subfields: Atomic and Molecular Physics, and Optics, Molecular Biology, Statistical and Nonlinear Physics

View Paper: https://www.semanticscholar.org/paper/d5e5023d1dbfd1b1dd8e1045bbc7290e934704b9

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In Atomic and Molecular Physics, and Optics

In Molecular Biology

In Statistical and Nonlinear Physics

Citations in the corpus

Stochastic resetting and applications (2019, background): “Second, an important question in biological systems is the efficiency of computation [152–154].”