Staphylococcal manipulation of host immune responses
By Vilasack Thammavongsa, H. Kim, D. Missiakas, O. Schneewind. 2015
537 citations recorded by the source corpus.
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.
Subfields: Infectious Diseases, Microbiology, Molecular Biology
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Citations in the corpus
- The wound microbiota: microbial mechanisms of impaired wound healing and infection (2024, unknown): “factor (Clf) and serine–aspartate repeat-containing protein (Sdr), can also activate and/or evade the immune system, allowing pathogens to gain intracellular access and cause infection 48,50 .”
- Exploiting dominant‐negative toxins to combat Staphylococcus aureus pathogenesis (2016, unknown): “Contributing to the challenge of therapeutic development is the assortment of virulence factors that S. aureus employs to subvert the host immune response [2,3,17].”
- Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes (2020, background): “aureus virulence is supported through a wide array of virulence factors (2), one class of which is the bicomponent leukocidins.”
- Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin (2019, background): “aureus commonly causes recurrent infections in the human host without the development of sterilizing immunity (8), suggesting that this bacterium is able to thwart the host immune response.”