Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

By J. Ansell, J. Hirsh, E. Hylek, A. Jacobson, M. Crowther, G. Palareti. Chest, 2008

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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage (2016, background): “Their use more than doubles the risk of spontaneous intraparenchymal hemorrhage [11] and is associated with 12–14 % of all intraparenchymal hemorrhages [1, 12].”
Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition) (2018, methodology): “Thereare many drug interactions with warfarin therapy that potentiate the anticoagulant effect, including concomitant administration of antiplatelet medications, heparin, and LMWH. 188,195,196 Recent clinical studies have demonstrated that patients with variations in the CYP2C9 and/or VKORC1 genes a”