Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.

By L. Hartmann, T. Sellers, Daniel J. Schaid, T. S. Frank, Cheryl L. Soderberg, Diana L. Sitta, M. Frost, C. Grant, J. Donohue, J. Woods and 5 more. Journal of the National Cancer Institute, 2001

785 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics

View Paper: https://www.semanticscholar.org/paper/d52e498a78d9ea866c84193216fa21798ba45ccb

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Citations in the corpus

• Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. (2004, background): “However, BRCA1/2 mutation status was unavailable for the initial analysis, and only 18 women in this series were later reported to be BRCA1/2 mutation carriers [5].”
• Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. (2006, background): “Clinical options for women at high genetic risk of breast cancer include screening starting at a young age,(19) the use of highly sensitive detection methods,(20) and prophylactic surgeries of the ovaries or breast.(21-27) Because prophylactic surgeries, while highly effective in reducing risk, are ”